Podwer Structure Control

Publication Reference: 
ARR-62-06
Author Last Name: 
Kohlus
Authors: 
Reinhard Kohlus
Report Type: 
ARR
Research Area: 
Particle Formation
Publication Year: 
2016
Publication Month: 
16
Country: 
Germany

The focus of the recent work was on the generation of different types of structure. Random

close structured granules as presented in previous years were investigated more

detailed regarding the packing density and primary particle distance distribution inside

a granule. Additional random loose structures were generated allowing porosity as additional

phase. Porous systems were generated using two different methods: fluid bed

granulation and a sintering method. Layered systems or core/shell systems were generated

using a fluid bed; a fine particle suspension was sprayed on larger core particles.

Additionally the particle-particle distance of coarse primary particles that was presented

as suitable structure measure last year was investigated more detailed. The goal was to

develop a theoretical calculation of particle-particle distance based on the known primary

particle size distribution. Results show a good agreement between values calculated

from X-ray micro-tomography images and values from theoretical calculations. Therefore

this theoretical particle-particle distance was used as structure measure in random close

structured granules.

The dissolution measurements of different sets of experiments showed that the dissolution

speed is dependent on two factors: amount of soluble material (fraction of surface

occupied by soluble material) and pore size or phase width of soluble materials. These

two factors are strongly connected and it is difficult to investigate one without the other.

Together a high fraction of soluble material and a high phase width leads to a faster dissolution

compared to granules with smaller phase width (or pore size) and fraction.

The mechanical strength of random close structured granules showed no explicit results

and was difficult to evaluate. Random loose structured granules on the other side showed

a higher strength for lower effective porosities. These results were as expected, the development

of a network of solid bridges between primary particles leads to stable granules

if more and thicker bridges are build.