Self-Assembled Monolayers as Nucleating Surfaces to Study Early Formation Pathways of Crystallographic Polymorphs

Executive Summary

groups, including carboxylates and amines, and other solvents.

crystals on the SAM surface, as well as exploration of other SAM surface functional

steps will include changing sample angle in order to increase the low number of observed

of yellow needles (YN), while methyl SAMs preferred red prisms (R). Next experimental

for selection of additional polymorphs. Besides Y, hydroxyl SAMs preferred the nucleation

surfaces. However, hydroxyl and methyl terminated SAMs showed a different tendency

that yellow crystal (Y) was the dominating polymorph on both -OH and -CH3 terminated

polymorph characterization of nucleated crystals. First experimental results demonstrated

jump at three different levels of supersaturation. Raman microscopy was applied for

solution and the nucleation was induced on the SAM surface by generating a temperature

project, control over the degree of supersaturation. SAMs were placed vertically in the

Crystallization by cooling experiments were conducted to allow, for the first time in this

[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) in toluene as solvent.

groups (-OH and -CH3) as nucleating surfaces for the organic model system 5-methyl-2-

based self-assembled monolayers (SAMs) with different terminal (omega) functional

number of industries. This project has moved to the formation of alkane-thiols on gold

as well as inorganic compounds are scientifically and technologically important to a

Understanding and control of crystallographic polymorphism and crystal habit of organic